✦ LIBER ✦
Synthesis of angiotensins, bradykinins and substance P octapeptides in which the residues Phe and Tyr have been replaced with car and of [Car1, Leu5]-enkephalin
✍ Scribed by Othmar Leukart; Emanuel Escher; Domenico Regoli; Robert Schwyzer
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- German
- Weight
- 475 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Thirteen peptides, analogues of bradykinin (BK), enkephalin, Substance P (SP) and [Sar^1^]‐angiotensin II ([Sar^1^]‐AT~II~) have been synthesized by the solid‐phase method. In all these peptides the residue Phe and Tyr were substituted with the boron‐containing amino‐acid L‐o‐carboranylalanine (Car). The purity and identity of the peptides were established by TLC., cellulose‐electrophoresis and amino acid analysis.