## Abstract The methyl ester of __N__βacetylneuraminic acid Ξ²βmethyl ketoside (Neu5Ac1Meβ2Ξ²βMe) (1) is used as common starting material for the synthesis of the title compounds. Combined derivatization reactions with reagents thiophosgene, __p__βcresol, benzoyl chloride, and acetic anhydride/pyridi
Synthesis of analogs of N-acetylneuraminic acid and their effect on CMP-sialate synthase
β Scribed by Charles R. Petrie III; Moheswar Sharma; Onda D. Simmons; Walter Korytnyk
- Book ID
- 102990081
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 665 KB
- Volume
- 186
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
To gain more insight into the structure-activity relationship of the enzymes of sialic acid metabolism we recently prepared a series of sialic acid analogues2-4 and determined their surface profiles 5,6. For CMP-sialate synthase to recognize its substrate, we found that the three hydrophilic functio
Methyl-2-R-chloro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate 2 respectively methyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate 3 were transformed by catalytic hydrogenation or by reduction with tributyltin hydride to the corresponding 2-deoxy derivatives 4 and 5, which gave after saponi