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Synthesis of an α-CH2CO2H functionalized tryptophan and its incorporation into an analogue of cholecystokinin.

✍ Scribed by Gregory T. Bourne; David C. Horwell; Martyn C. Pritchard

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
697 KB
Volume
47
Category
Article
ISSN
0040-4020

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✦ Synopsis

The synthesis of an a,a-disubstituted tryptophan derivative (2) predicted by computer asszstedmolecular modelling to have close structural and conformational analogy to the endogenous neuropeptide cholecystokinin (CCK) is described. Central to the synthesis of ( 2) is the alkylation of an isonitrile derivative of tryptophan.

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An improved synthesis of α-13C glycine and heteronuclear NMR studies of its incorporation into thioredoxin
✍ David S. Wishart; Brian D. Sykes; Frederic M. Richards 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 502 KB

## Abstract We present an improved method to easily prepare gram quantities of α‐^13^C glycine beginning from K^13^CN. The four step synthesis involves the production of an N, N‐diphenyl‐cyanoformamidine intermediate through the coupling of cyanide to N, N‐diphenylcarbodiimide. Subsequent reduction