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Synthesis of an Oligodeoxyribonucleotide Adduct of Mitomycin C by the Postoligomerization Method via a Triamino Mitosene

โœ Scribed by Champeil, Elise; Paz, Manuel M.; Ladwa, Sweta; Clement, Cristina C.; Zatorski, Andrzej; Tomasz, Maria


Book ID
126226904
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
434 KB
Volume
130
Category
Article
ISSN
0002-7863

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A new method for synthesis of 3'-end-phosphorylated DNA oligomers via the phosphoramidite method with allyl protection has been developed. This method is particularly useful for the preparation of derivatives with base-labile structures such as oligoDNA-OPO(OH)OCH2CH(R)Z, in which Z is an electron-w