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Synthesis of an iodine-123-labeled celecoxib analogue: a potential spect agent

✍ Scribed by George W. Kabalka; Arjun R. Mereddy; Hildegard M. Schuller

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
90 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

Celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1yl]-benzenesulfonamide) is an effective inhibitor of the cyclooxygenase-2 (COX-2). The synthesis of a no-carrier-added iodine-123-labeled analogue of celecoxib was accomplished in four steps for potential use in single photon tomography.

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