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SYNTHESIS OF AN ACTINOMYCIN ANALOG WITH SUBSTITUTED LACTONE OXYGENS

โœ Scribed by Meienhofer, Johannes ;Patel, Ravindra P.


Book ID
115096973
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
251 KB
Volume
3
Category
Article
ISSN
0020-7551

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Synthesis of an esperamicin core analog
โœ Harold Mastalerz; Terrence W Doyle; John F Kadow; Dolatrai M Vyas ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 198 KB

An esperamicin core analog 4 with an epoxide trigger like that found in the related enediyne, dynemicin, was prepared. Surprisingly, it was found to be relatively stable; the p-aminophenyl substituent did not facilitate epoxide solvolysis to the extent that had been anticipated. A mild acid, pyridin