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Synthesis of Aminooxy-Functionalized Lanthanide(III) Chelates for Carbonyl-Group Conjugation

✍ Scribed by Jari Hovinen

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 100 KB
Volume: 3
Category: Article
ISSN: 1612-1872
DOI: 10.1002/cbdv.200690032

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✦ Synopsis

Abstract

The syntheses of three new aminooxy‐tethered lanthanide(III) chelates, compounds 1–3, incorporating DOTA (=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid), DTPA (=diethylenetriaminepentaacetic acid), or a substituted terpyridine (2,2′,2″,2′′′‐[2,2′: 6′,2″‐terpyridine‐6,6″‐diylbis(methylenenitrilo)]tetraacetic acid), respectively, are described. Reagents 1–3 can be used for carbonyl ‘labeling’, as shown by the formation of the corresponding oxime‐ether bioconjugates of naltrexone (16) and 2‐deoxy‐β‐D‐glucose (17) (Scheme 4).

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