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Synthesis of All the Diastereomers of 2-Amino-3-hydroxy-4,5-dimethylhexanoic Acid

โœ Scribed by Spengler, Jan; Albericio, Fernando


Book ID
121864687
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
377 KB
Volume
2014
Category
Article
ISSN
1434-193X

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Stereoselective Synthesis of all Stereoi
โœ Susan Gair; Richard F.W Jackson*; Paul A Brown ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 501 KB

Diastereoselectivemethylationof the ketone 5a leads ro the anti-derivative4a; the other diastereoisomer 4b may be obrained by a deprotonatiotrheprotonationsequence. Each of the methylatedproductsmay be reducedstereoselectivelyin either sense by appropriatechoice of reagent, providinga route to all s