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Synthesis of all four isomers of (E)-4,5-dihydroxydec-2-enal using osmium-catalysed asymmetric dihydroxylation

โœ Scribed by Pietro Allevi; Giorgio Tarocco; Alessandra Longo; Mario Anastasia; Francesco Cajone


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
774 KB
Volume
8
Category
Article
ISSN
0957-4166

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The first synthesis of all possible ster
โœ Pietro Allevi; Pierangela Ciuffreda; Giorgio Tarocco; Mario Anastasia ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 465 KB

The first synthesis of the four possible isomers of (E)-4,5-dihydroxydec-2-enal, a cytotoxic product ofmicrosomal lipid peroxidation, is accomplished starting with D-and Larabinose, D-ribose and D-lyxose by an identical reaction sequence. Each pentose was diacetonised and subjected to a Wittig react