Synthesis of adenine 5'-O-sulfamoyl nucleosides related to nucleocidin
β Scribed by Shuman, Dennis A.; Robins, Roland K.; Robins, Morris J.
- Book ID
- 125491765
- Publisher
- American Chemical Society
- Year
- 1969
- Tongue
- English
- Weight
- 262 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
Summarv : The extended adenine nucleosides m and 3 have been prepared from D-ribose by a reasonably short sequence using the suitably functionalized intermediate 6. Sinefungin J\_ a fermentation product isolated from Streptomyces griseolus 1 and S.
5'-O-[N-(Anhacyl w imtxy~yJ)sulfi~noyl]uridines 4a+ 5a-e and 5'4-[N~isopoprl)sulh~yI]~ytibs 7-9 have been 8 -d and testcd againat herpes simplex Virus rype 2. condensation of 2',3'-0-isoproWlide-nv5'4-sulfamoyluridim with the N-hydmxysuccinimide esters of Boc-GIy, Boc-LA4 Boc-D-Ah and Boc-LPhe, gave