Synthesis of acyloxyalkyl acylphosphonates as potential prodrugs of the antiviral, trisodium phosphonoformate (foscarnet sodium)

✍ Scribed by Radhakrishnan P. Iyer; Lawrence R. Phillips; Jane A. Biddle; Dhiren R. Thakker; William Egan; Shizuko Aoki; Hiroaki Mitsuya

• Book ID: 104245000
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 274 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)93918-8

✦ Synopsis

Bis(trimethyl.rilyl) acylplzosphorrates via their silver salts couple with iodoalkyl esters to provide on efficient synthesis of tile corresponding acyloxyalkyl esfers as potential prodrugs of the antiviral agenr, trisoditm phmphotwformate.

These compounds were tested as inhibitors of HIV-l irt chronically infected 119 cells.