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Synthesis of acyl pyrophosphates. Application to the synthesis of nucleotide lipophilic prodrugs

✍ Scribed by D. Bonnaffé; B. Dupraz; J. Ughetto-Monfrin; A. Namane; T. Huynh Dinh

Book ID
103399820
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
258 KB
Volume
36
Category
Article
ISSN
0040-4039

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Pyrophosphate (PPi) content of Escherichia coli is increased manyfold when the growth of the cells is limited by inhibition of the synthesis of nucleotides. The accumulated PPi is immediately degraded when inhibition is released and growth allowed to resume. Other tested nutritional deficiencies (st