Synthesis of a vinylog of p-aminobenzoylglutamic acid
β Scribed by C. Dewitt Blanton Jr.; W. Lewis Nobles
- Publisher
- John Wiley and Sons
- Year
- 1963
- Tongue
- English
- Weight
- 191 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Applying essentially the synthetic procedures of Long and Troutman, which led to chloramphenicol, we have attempted to synthesize a vinylog of the antibiotic in order to study the application of the theory of vinylogy to pharmacological results. However, failure to achieve the desired synthesis has
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Chiral vinylogous amino sulfonic acids (vs-amino acids) were synthesized starting from either L-or D-Ξ±-amino acids via N-BocΟͺΞ±-amino aldehydes. Wittig-Horner reaction with methyl (or ethyl) diethylphosphoryl methanesulfonate and nBuLi gave the corresponding Ξ±,Ξ²-unsaturated sulfonates in high yield a