Synthesis of a Vicinal Tricarbonyl Amide Derivative of l -Phenylalanine
โ Scribed by Lai, Jack H.; Pham, Ha; Hangauer, David G.
- Book ID
- 118005064
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 135 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
Synthesis of Novel L-Phenylalanine Derivatives Substituted with a Keto Ylide as Stable Precursor of a Vicinal Tricarbonyl Moiety. -A masked vicinal tricarbonyl derivative (XI) which is suitable as building block for solid phase peptide synthesis, is prepared. The release of the interesting function
The Yoshimura intermediate in the total synthesis of bicyclomycin was prepared by intran~lecular addition of an amide to an ~ketoamide. The resulting unsymmetrical diketopiperazine was then converted to the diol-ether target.
The addition of primary amines to alkenyl vicinal tricarbonyls leads to Ssubstituted-3-hydroxypyrroles. This reaction has been employed in a synthesis of the 2formyl-3-methoxy-a,a'-bipyrrole precursor of the prodigiosin family of natural products.