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Synthesis of a versatile chiral synthon corresponding to the C(1) to C(7) segment of 14-membered macrolide antibiotics

โœ Scribed by Marco Born; Christoph Tamm


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
215 KB
Volume
30
Category
Article
ISSN
0040-4039

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A short synthesis of the C15โ€“C21 segment
โœ Kazi A. Shahid; Yong-Nan Li; Momotoshi Okazaki; Yoshihiro Shuto; Fumitaka Goto; ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 136 KB

A new approach was developed to versatile enantiopure stereotriads using chiral oxazaborolidinone-promoted asymmetric aldol reaction of a racemic aldehyde with a bromo silyl nucleophile. A short synthesis of the C 15 -C 21 segment of (+)-discodermolide was achieved by elongation of one of the stereo