Synthesis of a pyrimido[4,5-b]azepine analog of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)
β Scribed by Edward C. Taylor; James E. Dowling
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 213 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0960-894X
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## Abstract [^3^H] 5,10βdideazaβ5,6,7,8βtetrahydrofolate, DDATHF, was obtained by a two step process. First, 2n[^3^H~2~O] was produced in the reaction flask containing m[^1^HAc] by the reduction of n[PtO~2~] with ^3^H~2~, so that a 1[^3^H^+^]:18[^3^H^+^ + ^1^H^+^] ratio of solvent protic species in