Synthesis of a Peptidomimetic Tricyclic Tetrahydrobenzo[ i j ]quinoline as a VLA-4 Antagonist
β Scribed by Ho, Wen-Bin; Broka, Chris
- Book ID
- 123609809
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 94 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Novel constrained L-phenylalanine derivatives incorporating a benzazepinone or an azepinone ring were synthesized in 13 and 8 steps, respectively, employing a key base-catalyzed intramolecular cyclization reaction. The product, 2, was comparable in potency in a VCAM/VLA-4 ELISA assay to the correspo
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