✦ LIBER ✦

Synthesis of a novel heterospirocyclic 3-(N-methyl-N-phenylamino)-2H-azirine and its use as an amino acid equivalent in the preparation of a model tripeptide

✍ Scribed by José M. Villalgordo; Heinz Heimgartner

Publisher: Elsevier Science
Year: 1993
Tongue: French
Weight: 586 KB
Volume: 49
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)87199-4

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis of a novel heterospirocyclic 3-amino-2H-asirine based on the reaction between amide enolates and diphenylphosphorochloridate is described. This compound has been shown to be a useful amino acid equivalent and the synthesis of a model m@pdde was achieved in good overall yields.

Wipf, P. Synthese und Ko~ormationanalyse von Peptiden mit a,a-disubstituierten a-Aminosiiuren,

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis and Utili

ChemInform Abstract: Synthesis and Utilization of Chiral 3-N-Benzyl-N-methylaminoperhydropyrrolo[2,1-c][1,4]oxazin-4-one as a Novel Precursor for the Enantioselective Synthesis of α-Amino Acids and Their N-Methyl Derivatives.

✍ Ganesh Pandey; Parthasarathi Das 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 2 views

1-Methyl-3-trimethylsilylparabanic Acid

1-Methyl-3-trimethylsilylparabanic Acid as an Effective Reagent for the Preparation of N-Substituted (1-Methyl-2,5-dioxo-1,2,5H-imidazolin-4-yl)amines and Its Application to the Total Synthesis of Isonaamidines A and C, Antitumor Imidazole Alkaloids.

✍ Seikou Nakamura; Ikuo Kawasaki; Masayuki Yamashita; Shunsaku Ohta 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 133 KB 👁 2 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

Synthesis of Orthogonally Protected Bis(

Synthesis of Orthogonally Protected Bis(aminomethyl)malonic Acid, and Its Use as a Key Building Block in the Preparation of Cyclic Peptide Conjugates of 2-N-Alkyl-1,2,3,4-tetrahydroisoquinoline on a Solid Support

✍ Pasi Virta; Jaana Rosenberg; Tuomas Karskela; Petri Heinonen; Harri Lönnberg 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 297 KB 👁 2 views

A novel method for the synthesis of carb

A novel method for the synthesis of carbon-14-labeled N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]propanamide and its use in quantitative whole-body autoradiography studies

✍ William J. Wheeler; Sylvia H. Chay; Jennifer L. Herman; Douglas D. O'Bannon 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 183 KB 👁 1 views

## Abstract Sumitriptan (1), a non‐selective 5‐HT~1B/1D~ agonist is an effective therapeutic agent for the acute treatment of migraine, but it is contraindicated for use in patients with known heart disease. The first Selective Serotonin One F Receptor Agonist (SSOFRA), 5‐(4′‐fluorobenz‐amido)‐3‐(_