✦ LIBER ✦
Synthesis of a novel bioactive photoaffinity probe based on a leaf-movement factor with potential high binding affinity to its receptor molecule
✍ Scribed by Tomohiko Fujii; Takanori Sugimoto; Shosuke Yamamura; Minoru Ueda
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 131 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Nyctinastic leaf-movement is induced by the binding of the leaf-movement factor with a motor cell located in the pulvini of the plant. Some receptors of the leaf-movement factor should be involved in this biological event. We developed a novel photoaffinity probe (1) for the detection of receptor molecules. Probe compound 1 bears a photolabeling group on the 2%-position of the glycon moiety, which is near the potential binding site of the molecule with its receptor. This molecular design would be effective for the improvement of photolabeling yield.