Synthesis of a Novel Bicyclic Nucleoside with a 3,7-Anhydrooctofuranosyl Skeleton.
β Scribed by Myong Jung Kim; Moon Woo Chun
- Book ID
- 111699730
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 12 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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Nucleophilic ring-opening and rearrangement reaction of a furanopyrimidine nucleoside with anhydrous hydrazine provided a novel, 6,6-bicyclic pyrimidopyridazin-7-one nucleoside (dH, 4), whose structure was confirmed by X-ray crystallography. This novel nucleoside was converted to its 5%-triphosphate