Synthesis of a new class of imidazole-based cyclic peptides
β Scribed by Gebhard Haberhauer; Frank Rominger
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 184 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A new class of cyclic peptides based on dipeptidyl imidazoles is presented. Their structure consists of imidazole units alternating with standard amino acid residues and resembles naturally occurring marine cyclopeptides such as westiellamide and ascidiacyclamide.
π SIMILAR VOLUMES
A new method for the synthesis of cychc peptide libraries has been developed where the key cyclisation step involves reaction between a C-terminal cysteine side chain and an N-terminal bromoacyl group. We report conditions whereby liberation of peptides from the solid support and cyclisation occur c
## Abstract A new cysteineβbased disulfide linker for Fmoc solid phase peptide synthesis was developed (FmocβCys(3βmercaptoβ3βmethylbutanoic acid)OPp) that allows the onβresin assembly and side chain deprotection of cyclic peptides. Model peptides and a cyclic peptide library of the structure [aβaβ