✦ LIBER ✦

Synthesis of a new class of cathepsin B inhibitors exploiting a unique reaction cascade

✍ Scribed by Yoshimitsu Nagao; Shigeki Sano; Kenji Morimoto; Hisao Kakegawa; Tadanobu Takatani; Motoo Shiro; Nobuhiko Katunuma

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 223 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00177-5

No coin nor oath required. For personal study only.

✦ Synopsis

Chiral 5-substituted 3-pyrrolin-2-ones bearing L-Ile-L-Pro-OH or L-Phe-NHCH 2 Ph were successfully synthesized by utilizing a characteristic reaction cascade based on alkaline hydrolysis of the corresponding diethyl αhydroxy-α-(β-propiolamide)malonates. Among the synthesized chiral pyrrolinones, compound 5S-9 proved to be the most potent inhibitor against cathepsin B.

📜 SIMILAR VOLUMES

ChemInform Abstract: Discovery and Paral

ChemInform Abstract: Discovery and Parallel Synthesis of a New Class of Cathepsin K Inhibitors.

✍ Roger A. Smith; Ajay Bhargava; Christopher Browe; Jinshan Chen; Jacques Dumas; H 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 2 views

An efficient synthesis of new class of p

An efficient synthesis of new class of pyrazolo[3,4-b]pyridine-6-one derivatives by a novel cascade reaction

✍ Feng Shi; Junyong Zhang; Shujiang Tu; Runhong Jia; Yan Zhang; Bo Jiang; Hong Jia 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 335 KB

## Abstract magnified image A novel cascade reaction of 4‐arylidene‐2‐phenyl‐1,3‐oxazol‐5(4__H__)‐one with 3‐methyl‐1‐phenyl‐1__H__‐pyrazol‐5‐amine was described and a number of new pyrazolo[3,4‐__b__]pyridine‐6‐one derivatives were synthesized. This new protocol has the advantages of shorter time

ChemInform Abstract: An Efficient Synthe

ChemInform Abstract: An Efficient Synthesis of New Class of Pyrazolo[3,4-b]pyridine-6-one Derivatives by a Novel Cascade Reaction.

✍ Feng Shi; Junyong Zhang; Shujiang Tu; Runhong Jia; Yan Zhang; Bo Jiang; Hong Jia 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 26 KB 👁 2 views

Discovery of a New Class of Inhibitors o

Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented Synthesis

✍ Andrea Nören-Müller; Wolfram Wilk; Krishna Saxena; Harald Schwalbe; Markus Kaise 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 571 KB

Scheme 1. Retrosynthetic analysis of the cycloocta[b]indole target structure.

ChemInform Abstract: anti-HBV Agents. Pa

ChemInform Abstract: anti-HBV Agents. Part 1. Synthesis of Alisol A Derivatives: A New Class of Hepatitis B Virus Inhibitors.

✍ Quan Zhang; Zhi-Yong Jiang; Jie Luo; Pi Cheng; Yun-Bao Ma; Xue-Mei Zhang; Feng-X 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

Local anesthetics: A new class of partia

Local anesthetics: A new class of partial inhibitors of mitochondrial ATPase

✍ Aaron B. Adade; Derek Chignell; Garret Vanderkooi 📂 Article 📅 1984 🏛 Springer US 🌐 English ⚖ 462 KB