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Synthesis of a New Chiral Bisphospholane Ligand for the Rh(I)-Catalyzed Enantioselective Hydrogenation of Isomeric β-Acylamido Acrylates

✍ Scribed by Holz, Jens; Monsees, Axel; Jiao, Haijun; You, Jinsong; Komarov, Igor V.; Fischer, Christine; Drauz, Karlheinz; Börner, Armin


Book ID
120386821
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
143 KB
Volume
68
Category
Article
ISSN
0022-3263

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On the enantioselective hydrogenation of
✍ Detlef Heller; Jens Holz; Igor Komarov; Hans-Joachim Drexler; Jingsong You; Karh 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 231 KB

The rhodium(I)-catalyzed enantioselective hydrogenation of E-and Z-configured b-acylamido b-alkylacrylates as well as of isomeric mixtures has been investigated. As ligands 1,2-bisphospholanes like DuPHOS, BPE and Me 4 -BASPHOS have been tested, but also diphosphines forming seven-membered chelates