Synthesis of a mucin-type O-glycosylated amino acid, β-Gal-(1→3)-[α-Neu5Ac-(2→6)]-α-GalNAc-(1→3)-Ser
✍ Scribed by Hiroyuki Iijima; Tomoya Ogawa
- Book ID
- 107725801
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 882 KB
- Volume
- 186
- Category
- Article
- ISSN
- 0008-6215
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📜 SIMILAR VOLUMES
Glycopepfide (I), Neu5A~2-3Gall~l-4GlcNA~l-2Maactl-Ser, was synthesized using a chemoenzymatic strategy. Gal~l-4GlcNAcl~l\*2Man Ifisacd~ide was ~ using glycosidase assisted oligom:x:lutride synthesis. After coupling of this trisacchaxide with a sefine defivstive by chemical glycosylstion, sialic add
Two new glycosyl amino acids N'~-Fmoc-Ser[Ac4-fl-D-Galp-(1 ~ 3)-Ac2-a-D-GalN3P]-OPf p and N'~-Fmoc-Thr[Ac4-/3-D-Galp-(1 ~ 3)-Ac2-a-D-GalN3p]-OPf p were synthesized. Glycosylation of N'~-Fmoc-Ser-OPf p or N ~-Fmoc-Thr-OPfp with protected/3-o-Gal-( 1 -~ 3)-D-GaIN 3 donors afforded the glycosyl amino a