Synthesis of a morphine-6-glucuronide hapten, N-(4-aminobutyl)normorphine-6-glucuronide, and related haptens
✍ Scribed by Richard T. Brown; Neil K. Carter; Keith W. Lumbard; Feodor Scheinmann
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 230 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Protected morphine‐6‐glucuronide was converted into morphine‐[__N__‐methyl‐^14^C]‐6‐glucuronide by a three‐step procedure. Methyl (3‐pivaloylmorphin‐6‐yl 2,3,4‐tri‐__O__‐isobutyryl‐__β__‐D‐glucopyranosid)uronate was N‐demethylated by treatment with 1‐chloroethyl chloroformate to afford
The pharmacokinetics of morphine-6-glucuronide (M6G) after both intravenous dosing and nasal administration were studied in sheep. The nasal formulation consisted of M6G in combination with an absorption promoting delivery system in the form of chitosan. The mean half-life of M6G after intravenous a