Synthesis of a metal binding protein designed on the α/β scaffold of charybdotoxin*

Economy in Protein Design: Evolution of

Economy in Protein Design: Evolution of a Metal-Independent ββα Motif Based on the Zinc Finger Domains

✍ Struthers, Mary D.; Cheng, Richard P.; Imperiali, Barbara 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 260 KB

Chemical synthesis of a designed β-prote

Chemical synthesis of a designed β-protein through the flow-polyamide method

✍ BIANCHI, E. ;SOLLAZZO, M. ;TRAMONTANO, A. ;PESSI, A. 📂 Article 📅 2009 🏛 Wiley (Blackwell Publishing) 🌐 English ⚖ 922 KB

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of α4β1 Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold

✍ Jürgen Boer; Dirk Gottschling; Anja Schuster; Bernhard Holzmann; Horst Kessler 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of α4β1 Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold

✍ Jürgen Boer; Dirk Gottschling; Anja Schuster; Bernhard Holzmann; Horst Kessler 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and

Synthesis of a αMan(1→3)αMan(1→2)αMan Gl

Synthesis of a αMan(1→3)αMan(1→2)αMan Glycocluster Presented on aβ-Cyclodextrin Scaffold

✍ Clare Carpenter; Sergey A. Nepogodiev 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 198 KB

## Abstract Application of 6‐thio‐α‐ and β‐cyclodextrins as the core component for the construction of multivalent carbohydrate structures is described. The method employed for the attachment of monomeric glycosides to a cyclodextrin core is based on the efficient nucleophilic displacement of bromi

Non-Peptide αvβ3 antagonists. Part 6: De

Non-Peptide αvβ3 antagonists. Part 6: Design and synthesis of αvβ3 antagonists containing a pyridone or pyrazinone central scaffold

✍ Michael J Breslin; Mark E Duggan; Wasyl Halczenko; Carmen Fernandez-Metzler; Cec 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 192 KB