✦ LIBER ✦
Synthesis of a LEC14 nonasaccharide, a core-fucosylated, biantennary N-glycan with a novel GlcNAc residue in the core region
✍ Scribed by Ingo Prahl; Carlo Unverzagt
- Book ID
- 104211381
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 90 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The recently found core substitution of N-glycans termed LEC14 is characterized by a GlcNAc residue linked b(1,2) to the central b-mannoside. Starting from a pentasaccharide building block functionalized for core-fucosylated N-glycans the total synthesis of a protected LEC14 nonasaccharide was accomplished. The key step of the synthesis was the introduction of the additional b(1,2)-linked GlcNAc residue that was highly dependent on the solvent and appears to proceed via an amide acetal intermediate.