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Synthesis of a highly functionalised bicyclo[3.3.0]octane

โœ Scribed by Alan T. Hewson; David T. MacPherson


Book ID
104226353
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
127 KB
Volume
24
Category
Article
ISSN
0040-4039

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## Abstract The Michael addition of dimethyl malonate (12) to __tert__โ€butyl acrylate (11), carried out without solvent, affords the triester 13a in 88% yield on a kg scale. Selective partial hydrolysis of 13a produces the monoacid 13b almost quantitatively. The Kolbe electrolysis of 13b furnishes