Synthesis of a heterocyclic receptor for carboxylic acids

✍ Scribed by Gregory Moore; Vincent Levacher; Jean Bourguignon; Georges Dupas

• Book ID: 104211478
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 95 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01934-1

✦ Synopsis

The synthesis of a tricyclic receptor having a bowl shape and three binding points for carboxylic acids has been achieved starting from readily available 1-tetralone derivatives. This host possesses a six-membered lactam moiety and a carboxamide at the end of a flexible arm. The association constant with benzoic acid and the stoichiometry of the complex have been determined using 1 H NMR dilution experiments.