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Synthesis of a Glucose-Derived Tetrazole as a New β-Glucosidase Inhibitor. A New Synthesis of 1-Deoxynojirimycin

✍ Scribed by Philipp Ermert; Andrea Vasella

Publisher
John Wiley and Sons
Year
1991
Tongue
German
Weight
771 KB
Volume
74
Category
Article
ISSN
0018-019X

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✦ Synopsis

A number of glycosidase inhibitors, some of them with promising biological properties, have been isolated or designed. Among them are not only polyhydroxylated piperidines (e.g. 1-deoxynojirimycin (2) [I], nojirimycin (3) [2], and related compounds), polyhydroxylated pyrrolidines (e.g. DAB 1 [3]) and indolizidines (e.g. castanospermine (4) [4] and swainsonine [5]), but also analogues of glyconolactones (glucono-1,5-lactone [6], nojirilactame 5 [7], the amidine 6 [8], acylated hydroximolactones 7 [9], and lactone hydrazones 8 [lo]).

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