Synthesis of a Dinuclear ZnII–Calix[4]arene Enzyme Model with Additional General Base Groups – Catalytic Activity in Phosphate Diester Transesterification
✍ Scribed by Peter Molenveld; Johan F. J. Engbersen; David N. Reinhoudt
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 358 KB
- Volume
- 1999
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Calix [4]arenes modified at the upper rim with two pairs of p-nitrophenyl phosphate (HPNP). The kinetics of 3-Zn 2 were compared with a mononuclear complex 1-Zn and a dinuclear functional groups were synthesized and were used as starting materials for the synthesis of an enzyme model 3-complex 2-Zn 2 that lack the dimethylamino groups. A catalysis mechanism is proposed where the Zn II centers of 3-Zn 2 that has two Zn II centers and two dimethylamino groups. Under neutral conditions, this dinuclear metallo-enzyme Zn 2 cooperate in the activation of the phosphoryl group while one of the dimethylamino groups acts as a general base in model is catalytically active in the cleavage of the phosphate diester bond of the RNA model substrate 2-hydroxypropyl-the deprotonation of the hydroxyl group of HPNP.
enes functionalized at two upper rim positions have been