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Synthesis of a cyclic-thioether peptide which binds anti-cardiolipin antibodies

✍ Scribed by David S Jones; Christina A Gamino; Martina E Randow; Edward J Victoria; Lin Yu; Stephen M Coutts

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 238 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01292-1

No coin nor oath required. For personal study only.

✦ Synopsis

Thioether cyclized peptide analogue, 1, was synthesized using solid phase FMOC chemistry on HMPB-MBHA resin, ct-Methylproline was introduced as an FMOC-alanyl-a-methylproline dipeptide, and the thioether was incorporated as FMOC-protected thioether tetrapeptide intermediate, 8. Compound 1 has been shown to bind anti-cardiolipin antibodies.

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