✦ LIBER ✦
Synthesis of a carbon-14 labelled peptidyl carbamate human leukocyte elastase inhibitor and its immobilization on a tritiated water soluble polymer
✍ Scribed by William R. Banks; Frantisek Rypacek; George A. Digenis
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 371 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A carbon‐14 labelled hemisuccinate peptidyl human leukocyte elastase inhibitor, p‐nitrophenyl‐N‐(1,4‐(^14^C)‐succinyl‐L‐alanyl‐L‐alanyl‐prolylmethyl‐ N‐isopropyl carbamate, and a tritium labelled hydrophilic polymer, poly‐α, β‐[N(2‐hydroxy‐1‐[^3^H]‐ethyl)]‐D,L aspartamide were prepared and are reported here. The immobilization of the [^14^C]‐peptidyl carbamate onto the tritiated polymer to afford a double labelled macromolecular inhibitor of human leukocyte elastase is also illustrated.