Synthesis of 9β-methyl-2-alkyl-7-oxo-5-arylmorphans

✍ Scribed by James B. Thomas; Xiaoling Zheng; Lawrence E. Brieaddy; Jason P. Burgess; S. Wayne Mascarella; Scott E. Fix; Buddy E. Cantrell; Dennis M. Zimmerman; F. Ivy Carroll

• Book ID: 104259885
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 189 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01549-4

✦ Synopsis

A convergent synthetic approach to 913-methyl-2-alkyl-7-oxo-5-arylmorphans has been developed utilizing alkylation of the metalloenamine of 1,2,3,6-tetrahydro-4-aryl-l-alkylpyridines with 2-(chloromethyl)-3,5-dioxahex-1-ene (Okahara's reagent).