✦ LIBER ✦

Synthesis of 9,9-Disubstituted 9H-Pyrrolo[1,2-a]indoles by Hydriodic Acid-Catalyzed Cyclization of 1-[2-(1-Aryl(or methyl)ethenyl)phenyl]-1H-pyrroles

✍ Scribed by Kazuhiro Kobayashi; Kenichi Hashimoto; Hiroo Hashimoto; Hideaki Kondo; Hisatoshi Konishi

Publisher: John Wiley and Sons
Year: 2011
Tongue: German
Weight: 152 KB
Volume: 94
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201100091

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✦ Synopsis

Abstract

A novel method is reported for the synthesis of 9,9‐disubstituted 9__H__‐pyrrolo[1,2‐a]indoles. Cyclization of 1‐[2‐(1‐aryl(or methyl)ethenyl)phenyl]‐1__H__‐pyrroles, which can be easily prepared from 2‐(1‐aryl(or methyl)ethenyl)anilines, proceeds smoothly, in general, at 0° in the presence of a catalytic (or an equimolar) amount of HI in MeCN to provide the desired products.

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