A novel synthesis of AzddMAP and AzddGuo is described starting from 1, ## 2-0-isopropylidene-alpha-D-xylofuranose. The key step in this synthesis involves the replacement of a diphenyl carbamoyl protecting group in the purine 6-position by methanol. In 1987 Hartmann, Hunsmann, and Eckstein (1) re
Synthesis of 9-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-2,6-diaminopurine (AzddDAP)
✍ Scribed by P. Herdewijn; A. Van Aerschot
- Book ID
- 104233078
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 198 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
1-(2-O-Acetyl-3,5,6-tri-O-benzoyl-beta-D-glucofuranosyl)thymine (1) was converted into the 2,2'-anhydro derivative 4 by selective deacetylation, mesylation, and treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene. Cleavage of the 2,2'-anhydro ring in 4 with hydrogen bromide or hydrogen chloride led to
## Abstract The α,β‐unsaturated D‐sugar aldehyde 2, prepared from tri‐__O__‐acetyl‐D‐glucal, was converted into 1‐__O__‐acetyl‐3‐azido‐2,3‐dideoxy‐α‐D‐__arabino__‐pyranose (3) by reaction with sodium azide in a mixture of acetic acid and water followed by acetylation. Reaction of 3 with silylated p