Synthesis of 7,8-dimethoxy and 7,8-methylenedioxy isochroman-3-ones an efficient synthesis of (±) tetrahydropalmatine and (±) canadine
✍ Scribed by N.S. Narasimhan; R.S. Mali; B.K. Kulkarni
- Book ID
- 104241750
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 121 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Isochroman-3-ones are importent synthons. They furnish benzocyclobutenes which can undergo cycloxddition re,actions leading to a variety of com?oundsl and also provide efficient route to the berbine alkaloids'.
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## Abstract ( ± )‐5,5″‐Dihydroxy‐7,7″‐dimethoxy‐8,8″‐biflavone (( ± )‐l) was resolved into its optically pare forms __via__ the formation and recrystallization of its (2__R__)‐ and (2__S__)‐1‐(4‐toluenesulfonyl)prolylate, and the methylated derivatives of (+)‐ and (‐)‐1 were also prepared. The abso