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Synthesis of 7,8-dichloro-6-Nitro-1H-1,5-benzodiazepine-2,4-(3H, 5H)-dione as a potential NMDA receptor glycine site antagonist

โœ Scribed by Ki-Jun Hwang


Book ID
105672484
Publisher
Springer
Year
2000
Tongue
English
Weight
307 KB
Volume
23
Category
Article
ISSN
0253-6269

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Synthesis of 7-chloro-2,3-dihydro-2-[1-(
โœ Dean G. Brown; Rebecca A. Urbanek; Thomas M. Bare; Frances M. McLaren; Carey L. ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 168 KB

Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino [4,5-b]quinoline-1,4,10(5H)-triones (2) have been identified as being potent and selective NMDA glycine-site antagonists. Increasing size of the alkyl substituent on the alpha-carbon led to a progressive decrease in bindin