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Synthesis of 7,6-Fused Bicyclic Lactams for Use as Beta-Turn Mimics.

✍ Scribed by Omar Morales; Wesley Seide; Samuel E. Watson

Publisher
John Wiley and Sons
Year
2006
Weight
21 KB
Volume
37
Category
Article
ISSN
0931-7597

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A new scaffold for dipeptide β-turn mime
A new scaffold for dipeptide β-turn mimetics: Expeditious synthesis of an unsaturated 6,5-fused bicyclic lactam
✍ Régis Millet; Raymond Houssin; Jean-Pierre Hénichart; Benoît Rigo 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 294 KB

## Abstract Reported here is an easy and short synthesis of 6‐acetamido‐5‐oxo‐1,2,3,5,6,7‐hexahydro‐3‐indolizine‐carboxylic acid, originating from β‐enaminoesters derived from pyroglutamic acid. This key compound has been used as a scaffold in the synthesis of dipeptido mimetics.