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Synthesis of 7-chloro-9-trifluoromethyl-/7-fluorophenothiazines

✍ Scribed by Bhawani Singh Rathore; V. Gupta; R. R. Gupta; M. Kumar

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
115 KB
Volume
18
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Synthesis of 7‐chloro‐9‐trifluoromethyl‐/7‐fluorophenothiazines is reported by Smiles rearrangement of 5‐chloro‐3‐trifluoromethyl‐/5‐fluoro‐2‐formamido‐2′‐nitrodiphenyl sulfides. The later were obtained by the formylation of 2‐amino‐5‐chloro‐7‐trifluoromethyl‐/5‐fluoro‐2′‐nitrodiphenyl sulfides, which were prepared by the condensation of 2‐amino‐5‐fluoro‐/5‐chloro‐3‐trifluoromethyl benzenethiols with o‐halonitrobenzenes. 1‐Nitrophenothiazines have also been synthesized by the condensation of 2‐aminobenzenethiols with o‐halonitrobenzenes, involving Smiles rearrangement in situ. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:81–86, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20235

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