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Synthesis of 6-substituted thieno[3,2-b]pyrroles. Analogs of tryptophan, tryptamine, and indoleacetic acid

โœ Scribed by Humphries, A. J.; Keener, Ronald L.; Yano, Kunihiko.; Skelton, F. S.; Freiter, Edward.; Snyder, H. R.


Book ID
120045627
Publisher
American Chemical Society
Year
1972
Tongue
English
Weight
681 KB
Volume
37
Category
Article
ISSN
0022-3263

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Synthesis of certain 5-substituted thien
โœ Hwang-Hsing Chen; Jesse A. May; Vincent M. Lynch ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 669 KB

A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5-substituted thieno[2,3-b]thiophene-2-sulfonamides provided the first examples of thiophene[2,3-b]thiophene-2-sulfonamide 6,6-dioxides. These cyclic vinyl sulfones readily underwent add