✦ LIBER ✦
Synthesis of 6-(Nα-acetyl-lysyl)-11-norleucine-substance P-(6–11)-hexapeptide labelled with tritium on the phenylalanine residue in position 7
✍ Scribed by M. Bienert; H. Niedrich; I. Teplán; K. Medzihradszky
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 504 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
p-Ac-Lys-(Phe-4-3 H) -Phe-Gly-Leu-Nle-NH2, a modified Substance P fragment with full activity on smooth muscle has been prepared by catalytic tritiation of the corresponding precursor peptide containing pchlorophenylalanine in position 7.
The precursor peptide has been synthesized by stepwise couplings from the C-terminal end, using t-butyloxycarbonyl-amino acid 2,4,5-trichlorophenyl esters. The specific radioactivity o f the tritiated product obtained was 23 Ci/mmole.