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Synthesis of 6-ethynylpurine derivatives

✍ Scribed by András Nagy; András Kotschy

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
116 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of 6-(arylethynyl)purine derivatives are synthesized from the corresponding 6-halopurines via sequential and 'one-pot' Sonogashira-coupling reactions. The nature of the acetylene source was found to have a profound influence on the efficiency of the process. In sequential couplings, 2-methyl-but-3-yn-2-ol was found to be an efficient acetylene surrogate, while in the 'one-pot' reaction, 1-ethynylcyclohexanol gave superior results.

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