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Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions

โœ Scribed by Graeme Cooke; Hugues Augier de Cremiers; Vincent M Rotello; Brian Tarbit; Petra E Vanderstraeten


Book ID
108371132
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
81 KB
Volume
57
Category
Article
ISSN
0040-4020

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A synthesis of 2- and 4(5)-(2-pyridinyl)
โœ A.S. Bell; D.A. Roberts; K.S. Ruddock ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 198 KB

Absfrucf N-Substltuted lmldazolylzlnc chlorides were reacted wlth 2bromopyrldlne In the presence of Pd(PPh3)4 and a two-fold excess of ZnCl2 to afford cross-coupled products In 58-93% ylelds. Deprotection provlded convenient routes to 2-or 4(5)-(2-pyrtdlnyl)lmldazoles.