Synthesis of 6-Alkyluridines from 6-Cyanouridine via Zinc(II) Chloride-Catalyzed Nucleophilic Substitution with Alkyl Grignard Reagents

Synthesis of 6-alkyl and 6-aryl substitu

Synthesis of 6-alkyl and 6-aryl substituted 9-β-D-ribofuranosyl purines via the nickel catalyzed coupling of grignard reagents to 2′,3′,5′-tris-0-(t-butyldimethylsilysl)-9-β-D-ribofuranosyl-6-chloropurine

✍ Donald E. Bergstrom; P.Anantha Reddy 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 257 KB

A series of 6-substituted purine nucleosides have been synthesized in mcderate yield by the nickel catalyzed cross coupling reaction between alkyl-and aryl-Griqnard reagents and 2',3',5'-tris-@-(t-butyldimethylsilyl)-9-~-~-ribofuranosy1-6-chloropurine. Adenosine analogues with alkyl and aryl group l