✦ LIBER ✦
Synthesis of 6-alk-1′-enyl penicillanic acids; double bond isosteres of the side-chain amide linkage in penicillins
✍ Scribed by Stephen A. Matlin; Lam Chan
- Book ID
- 104241590
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 194 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Two penicillin analogues have been prepared which incorporate C=C bonds at C60 and C6B respectively, in place of the normal side-chain NHCO group. The concept of isosteric replacement of an amide function by a carbon-carbon double bond has recently been exemplified in the synthesis of active enkephalin analogues.