𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 5H-1,2,3-triazolo[4,3-a][2]benzazepines from the baylis-hillman adducts of 2-alkynylbenzaldehydes

✍ Scribed by Seung Ho Ko; Kee-Jung Lee

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
141 KB
Volume
41
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The facile synthesis of 5__H__‐1,2,3‐triazolo[4,3‐a][2]benzazepines 5a‐d by the intramolecular 1,3‐dipolar cycloaddition reaction of 2‐alkynylphenylallyl azides 4a‐d is described. The latter were readily obtained from 2‐alkynylbenzaldehydes 1a‐d through the Baylis‐Hillman adducts 2a‐d followed by acetylation to compounds 3a‐d and nucleophilic substitution by azide to compounds 4a‐d.

📜 SIMILAR VOLUMES

The [3 + 2] cycloaddition route to 5-car
The [3 + 2] cycloaddition route to 5-carbomethoxy-4h-1,2,3-triazolo[1,5-a][1]benzazepines from baylis-hillman acetates of 2-azidobenzaldehydes
✍ Young Seok Song; Kee-Jung Lee 📂 Article 📅 2006 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 261 KB

## Abstract magnified image A new, simple synthesis of 5‐carbomethoxy‐4__H__‐1,2,3‐triazolo[1,5‐__a__][1]benzazepines from the reaction of several Baylis‐Hillman acetates of 2‐azidobenzaldehydes with alkynide Grignard reagents such as phenylethynyl‐, 1‐propynyl‐ and ethynylmagnesium bromides follo

Synthesis of 4H-tetrazolo[1,5-a][1]benza
Synthesis of 4H-tetrazolo[1,5-a][1]benzazepines from the baylis-hillman adducts of 2-azidobenzaldehyde
✍ Chang Hoon Lee; Young Seok Song; Hyun In Cho; Je Woo Yang; Kee-Jung Lee 📂 Article 📅 2003 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 38 KB

## Abstract Novel heterocycles, 4__H__‐tetrazolo[1,5‐__a__][1]benzazepines **6** were prepared by the intramolecular 1,3‐dipolar cycloaddition reaction of azidophenylcyanomethyl compounds **5.** The latter were readily obtained from 2‐azidobenzaldehyde through the Baylis‐Hillman adducts **3** follo