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Synthesis of 5,8-dimethoxy-2(1H)-quinolinones by intramolecular Wittig reaction

✍ Scribed by Ferrer, Pedro ;Avendaño, Carmen ;Söllhuber, Mónica

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
444 KB
Volume
1995
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The title compounds 12, which are key intermediates for antitumoral diazaquinomycin A analogues, are obtained by intramolecular Wittig reaction of 1‐[3′,6′‐dimethoxy‐2′‐(α‐oxoacylamino)phenyl]alkyltriphenylphosphonium salts 11, which are prepared via lithiation of 2′,5′‐dimethoxy‐N‐pivaloylaniline 6. The applicability of this route to polysubstituted 2(1__H__)‐quinolinones 12 and 17 is examined.

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