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Synthesis of 5,6-Dihydro-OSW-1 and its antitumor activities

✍ Scribed by Le-Hua Deng; Hao Wu; Biao Yu; Man-Rong Jiang; Jia-Rui Wu

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
490 KB
Volume
22
Category
Article
ISSN
0256-7660

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✦ Synopsis

Abstract

5,6‐Dihydro‐OSW‐1 (1) was synthesized following our previous procedure for the total synthesis of OSW‐1. This compound demonstrated slightly stronger potency than that of OSW‐1 against the growth of cancer cells.

πŸ“œ SIMILAR VOLUMES

Synthesis and Antitumor Activity of the
Synthesis and Antitumor Activity of the Estrane Analogue of OSW-1
✍ Yuji Matsuya; Seiji Masuda; Noriko Ohsawa; Solange Adam; ThΓ©ophile Tschamber; Ja πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 133 KB

## Abstract The estrane analogue of OSW‐1, a potent antitumor natural saponin, was efficiently synthesized from estrone in 12 steps. The cytostatic activity of the compound against several human malignant tumor cells was examined and compared to those of the natural OSW‐1 and cisplatin, the results