Synthesis of 5-Substituted Resorcinol Derivatives via Cross-Coupling Reactions

✍ Scribed by Georg C. Dol; Paul C. J. Kamer; Piet W. N. M. van Leeuwen

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 391 KB
• Volume: 1998
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(199802)1998:2<359::aid-ejoc359>3.0.co;2-n

✦ Synopsis

Suzuki and Stille cross-coupling reactions were utilized in 1-trimethyltin-3,5-dimethoxybenzene and 3,5-dimethoxyphenyl boronic acid. 5-Allyl-1,3-dimethoxybenzene and 3,5-the synthesis of 5-substituted 1,3-dimethoxybenzene and 5substituted resorcinol derivatives. The substituted resorcinol dimethoxybiphenyl derivatives were obtained via cross coupling reactions under mild conditions. HI, BBr 3 and AlI 3 were derivatives were obtained in only three steps from inexpensive reagents. 1,3-Dimethoxybenzoic acid and 1-chloro-3,5-used to demethylate these dimethoxybenzenes into their resorcinol derivatives. dimethoxybenzene were transformed into 1-iodo-, 1-bromo-,